Rio De Janerio, Brazil: Rio De Janerio is easily one of the best cities in South America to visit (and probably one of the most famous).
Cusco, Peru: Perched within the Andes Mountains, Cusco is easily one of the best cities in South America to visit.
Santiago, Chile: Santiago is one of the best cities in South America where skyscrapers and mountains almost intertwine.
Ushuaia, Argentina: Famous as being the most southernly city in all the world.
Buenos Aires, Argentina: Probably known as the shopping capital of Argentina, Buenos Aires.
Montevideo, Uruguay: Relatively near to Buenos Aires is the capital city of Uruguay.
San Pedro de Atacama, Chile: For me, I always recommend San Pedro de Atacama if you like your city life a tad more rustic.
Sao Paulo, Brazil: Sao Paulo, the largest and one of the best cities in South America.
Paramaribo, Suriname: Quite a few people seem to have never even heard of Suriname.
Lima, Peru: Founded in 1535 by Francisco Pizarro, Peru’s capital city is one of the best cities in South America to visit.